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The dosage of pantoprazole sodium for injection in patients with pathological hypersecretory conditions including Zollinger-Ellison Syndrome varies with individual patients. The recommended adult dosage is 80 mg intravenously every 12 hours. The frequency of dosing can be adjusted to individual patient needs based on acid output measurements. If you are allergic to medicines containing other proton pump inhibitors. These tablets are not recommended for use in children below 12 years. Poor metabolizers exhibited approximately 10-fold lower apparent oral clearance compared to extensive metabolizers.

Oral, 40 mg per day for up to four weeks

In the treatment of gastroesophageal reflux disease and gastric ulcer, relief of symptoms usually occurs within 2 weeks and healing within 4 weeks. Therapy should not exceed 8 weeks. Controlled studies of pantoprazole used as maintenance therapy to prevent reflux esophagitis recurrence have not been conducted beyond 12 months, although in a limited number of patients have received continuous maintenance treatment for up to 8 years. In the treatment of duodenal ulcer, relief of symptoms usually occurs within 1 week and healing within 2 weeks. Therapy should not exceed 4 weeks. Pantoprazole is in a class of called which block the production of acid by the stomach. Other drugs in the same class include and . Proton pump inhibitors are used for the treatment of conditions such as ulcers, and Zollinger-Ellison syndrome that are caused by stomach acid. What is pantoprazole?

Use of pantozol

All medicines may cause side effects, but many people have no, or minor, side effects. Oral, 40 mg per day for up to four weeks. Pantoprazole sodium for injection is indicated for short-term treatment 7 to 10 days of adult patients with gastroesophageal reflux disease GERD and a history of erosive esophagitis. Because pantoprazole has been shown to cause tumorigenic effects in animals, a decision should be made as to whether nursing should be discontinued or the medication withdrawn, taking into account the importance of pantoprazole to the mother. In a clinical pharmacology study, pantoprazole 40 mg given orally once daily for 2 weeks had no effect on the levels of the following hormones: cortisol, testosterone, triiodothyronine T 3 thyroxine T 4 thyroid-stimulating hormone, thyronine-binding protein, parathyroid hormone, insulin, glucagon, renin, aldosterone, follicle-stimulating hormone, luteinizing hormone, prolactin and growth hormone.

Does pantozol interact with other medications

PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using pantoprazole delayed-release tablets while you are pregnant. Pantoprazole delayed-release tablets are found in breast milk. Do not breast-feed while taking pantoprazole delayed-release tablets. Rockville, MD, 1998. p 548. Low blood magnesium levels have been reported rarely in patients taking PPIs for at least 3 months. In most cases, this effect was seen after a year of treatment. If you will be taking pantoprazole delayed-release tablets for a long time, or if you take certain other medicines eg, digoxin, diuretics your doctor may perform lab tests to check for low blood magnesium levels. Seek medical attention right away if you experience symptoms of low blood magnesium levels eg, dizziness; fast or irregular heartbeat; involuntary muscle movements; jitteriness or tremors; muscle aches, cramps, pain, spasms, or weakness; seizures.



For Intravenous Infusion Only

Acid secretion returns to normal levels without rebound hypersecretion within 1 week. Pantoprazole is indicated for the prevention of relapse in patients with reflux esophagitis. To evaluate the effectiveness of pantoprazole sodium for injection as an initial treatment to suppress gastric acid secretion, two studies were conducted. No adverse effects were reported in single-agent overdose with pantoprazole in doses of 400 and 600 mg. Death following multi-agent ingestion was attributed to chloroquine and zopiclone rather than pantoprazole. If you have ever had a skin reaction after treatment with a medicine similar to Pantoprazole that reduces stomach acid. Intravenous infusion, 40 mg at a rate of 3 mg 7 mL per minute over approximately fifteen minutes each day for seven to ten days. Full to partial recovery of these effects were noted in animals of both age groups following a recovery period. The active substance is pantoprazole. Pantoprazole delayed-release tablets should be used with caution in Asian patients; the risk of side effects may be increased in these patients. Pantoprazole was more effective than placebo and ranitidine at improving the symptoms of acid reflux. In the first study, 74% of the patients taking pantoprazole 80 out of 108 and 43% of those taking placebo 48 out of 111 had no heartburn after two weeks. Pantoprazole was also more effective than placebo at reducing symptoms of acid regurgitation. In the second study, 70% of the patients taking pantoprazole 121 out of 172 and 59% of those talking ranitidine 102 out of 172 had no heartburn after two weeks of treatment. What is the risk associated with Pantozol Control? Midazolam HCl has been shown to be incompatible with Y-site administration of pantoprazole sodium for injection. Pantoprazole sodium for injection may not be compatible with products containing zinc. When pantoprazole sodium for injection is administered through a Y-site, immediately stop use if precipitation or discoloration occurs. Warfarin and phenprocoumon, which affect the thickening, or thinning of the blood. You may need further checks. For adult patients who are CYP2C19 poor metabolizers, no dosage adjustment is needed. The data from these studies revealed that animals in both age groups respond to pantoprazole in a similar manner. In a 5-day study of oral pantoprazole with 40 and 60 mg doses in healthy subjects, following the last dose on day 5, median 24-hour serum gastrin concentrations were elevated by 3 to 4 fold compared to placebo in both 40 and 60 mg dose groups. However, by 24 hours following the last dose, median serum gastrin concentrations for both groups returned to normal levels. The clinical significance of this finding is not clear.



Oral, 40 mg per day for up to two weeks

Posted 8 Feb 2012 by Drugs. Published observational studies suggest that PPI therapy like pantoprazole sodium may be associated with an increased risk of Clostridium difficile associated diarrhea, especially in hospitalized patients. For Intravenous Infusion Only. Always take this medicine exactly as your doctor or pharmacist has told you. Acute interstitial nephritis has been observed in patients taking PPIs including pantoprazole sodium for injection. Pantoprazole, like other proton-pump inhibitors, blocks the enzyme in the wall of the stomach that produces acid. By blocking the enzyme, the production of acid is decreased, and this allows the stomach and to heal. As an aid to patient consultation, refer to Advice for the Patient, Pantoprazole Systemic. Long-term treatment eg, longer than 3 years with medicines like this one has rarely caused low vitamin B12 levels. Discuss any questions or concerns with your doctor. The stability of the compound in aqueous solution is pH-dependent. Approximately 3% of Caucasians and African-Americans and between 17% and 23% of Asians have deficiency of the CYP2C19 hepatic enzyme system, resulting in slow metabolism. Although certain pharmacokinetic values such as half-life and serum concentrations of pantoprazole will be enhanced in these patients, no specific dose adjustments are recommended, and no differences in safety or efficacy are apparent. If you have any questions about pantoprazole delayed-release tablets, please talk with your doctor, pharmacist, or other health care provider. Pantoprazole is extensively metabolized in the liver through the cytochrome P450 CYP system. Pantoprazole metabolism is independent of the route of administration intravenous or oral. The main metabolic pathway is demethylation, by CYP2C19, with subsequent sulfation; other metabolic pathways include oxidation by CYP3A4. There is no evidence that any of the pantoprazole metabolites have significant pharmacologic activity. Novo mesto, Šmarješka cesta 6, 8501 Novo mesto, Slovenia. arava



Pantozol brand names

No gender-related differences in the safety profile of intravenous pantoprazole were seen in international trials involving 166 men and 120 women with erosive esophagitis associated with GERD. In the other study of 14 patients 38 to 67 years; 5 female; 2 Black, 12 White with Zollinger-Ellison Syndrome, treatment was switched from an oral proton pump inhibitor to pantoprazole sodium for injection. Pantoprazole sodium for injection maintained or improved control of gastric acid secretion. The CHMP noted that pantoprazole 20 mg was effective in the short-term treatment of reflux symptoms and that there is a long safety experience with the medicine as a prescription medicine. It was also of the opinion that, based on the experience of the use of pantoprazole, the availability of Pantozol Control without medical supervision is appropriate. Adequate and well-controlled studies in humans have not been done. Pantoprazole 40 mg tablets instead, one a day. After healing, you can reduce the dose back again to one tablet 20 mg a day. Blister pack: Store in the original package in order to protect from moisture. American Council on Exercise: “The Best Time to Exercise. ebeco.info proventil



See Usual adult dose

Ask your health care provider any questions you may have about how to use pantoprazole delayed-release tablets. Pantoprazole peak serum concentration C max and area under the serum concentration-time curve AUC increase in a manner proportional to intravenous doses from 10 mg to 80 mg. Pantoprazole does not accumulate and its pharmacokinetics are unaltered with multiple daily dosing. Following the administration of pantoprazole sodium for injection, the serum concentration of pantoprazole declines biexponentially with a terminal elimination half-life of approximately one hour. Do NOT change your dose, stop taking pantoprazole delayed-release tablets, or take pantoprazole delayed-release tablets for longer than prescribed without checking with your doctor. SD rats after 17 months, most likely due to elevated gastrin levels during chronic therapy. ECL-cell neoplasms did not occur over 24 months observations in mice receiving 5, 25, or 150 mg per kg daily. Because pantoprazole has been in use for many years, the applicant presented data from the scientific literature. The applicant also presented information from two main studies looking at the effects of pantoprazole 20 mg in a total of 563 adults who had symptoms of acid reflux, including at least one episode of heartburn in the three days before the studies began. The first study compared pantoprazole with placebo a dummy treatment in 219 adults, and the second compared it with ranitidine another medicine used to treat acid reflux symptoms in 344 adults. The main measure of effectiveness was the number of patients with symptoms of heartburn over the first two weeks of treatment. What benefit has Pantozol Control shown during the studies? Pantoprazole is indicated for short-term up to 4 weeks treatment for symptom relief and healing in patients with active duodenal ulcer. If you have any further questions on the use of this medicine, ask your doctor or pharmacist. Some medical conditions may interact with pantoprazole delayed-release tablets.



Pantozol dosage

In another placebo-controlled, 7-day study of 40 mg intravenous or oral pantoprazole in patients with GERD and a history of erosive esophagitis, the mean serum gastrin concentration increased approximately 50% from baseline and as compared with placebo, but remained within the normal range. Caucasians and African-Americans and 17 to 23% of Asians. Pantoprazole and its metabolites are excreted in the milk of rats. Pantoprazole excretion in human milk has been detected in a study of a single nursing mother after a single 40 mg oral dose. The clinical relevance of this finding is not known. Many drugs which are excreted in human milk have a potential for serious adverse reactions in nursing infants. Based on the potential for tumorigenicity shown for pantoprazole in rodent carcinogenicity studies, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the benefit of the drug to the mother. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. There are no adequate data from the use of pantoprazole in pregnant women. Excretion into human milk has been reported. Pantoprazole delayed-release tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people. There are no data available on the effects of intravenous pantoprazole on ECL cells. Pantoprazole-containing medicines have been available in the European Union EU since 1994. The reference medicine, Pantozol, is only available with a prescription. It is used for long-term treatments and is also used to treat a wider range of gastrointestinal diseases conditions affecting the gut than Pantozol Control. How has Pantozol Control been studied? Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, hands, eyes, throat, or tongue; unusual hoarseness; bloody or watery stools; bone pain; chest pain; fast or irregular heartbeat; fever, chills, or sore throat; red, swollen, blistered, or peeling skin; severe or persistent diarrhea or stomach pain; severe or persistent nausea or vomiting; stomach cramps; symptoms of kidney problems eg, not able to pass urine, change in the amount of urine produced, blood in the urine, a big weight gain; symptoms of liver problems eg, yellowing of the skin or eyes, dark urine, pale stools, nausea, loss of appetite, unusual tiredness; unexplained weight loss; unusual bruising or bleeding; vision changes. If you have reduced body stores or risk factors for reduced vitamin B12 and receive pantoprazole long-term treatment. The serum protein binding of pantoprazole is about 98%, primarily to albumin. No dose adjustment of clopidogrel is necessary when administered with an approved dose of pantoprazole sodium. The most common side effects with Pantozol Control seen in around 1 patient in 100 are diarrhoea and headache. For the full list of all side effects reported with pantoprazole, see the package leaflet. It is used for treating acid-related diseases of the stomach and intestine. Swallow tablets whole. Do not break, chew, or crush. Very high 98%; primarily to albumin. clavaseptin buy now store canada



What are the side effects of pantoprazole?

Sodium Chloride Injection, USP. In patients with severe renal impairment, pharmacokinetic parameters for pantoprazole were similar to those of healthy subjects. No dosage adjustment is necessary in patients with renal impairment or in patients undergoing hemodialysis. The active substance in Pantozol Control, pantoprazole, is a proton-pump inhibitor. Inside Science: “Time of Day Could Impact Athletes' Performance Peak. There was also no interaction with concomitantly administered antacids. Pantoprazole, although metabolized by hepatic cytochrome P 450 systems, does not appear to either inhibit or induce cytochrome P 450 enzyme activity. To date, no clinically significant interactions have been noted for such commonly used drugs as diazepam, phenytoin, nifedipine, theophylline, digoxin, warfarin, or oral contraceptives. Hematologic: leukopenia reported in ex-U. The 20 mg gastro-resistant tablets are light brownish yellow, oval, slightly biconvex tablets. Use pantoprazole delayed-release tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions. Once gastric acid secretion was controlled, there was no evidence of tolerance during this 7 day study. Basal acid secretion was maintained below target levels for at least 24 hours in all patients and through the end of treatment in these studies 3 to 7 days in all but 1 patient who required a dose adjustment guided by acid output measurements until acid control was achieved. In both studies, doses were adjusted to the individual patient need, but gastric acid secretion was controlled in greater than 80% of patients by a starting regimen of 80 mg q12h. Co-administration of pantoprazole in healthy subjects and in transplant patients receiving MMF has been reported to reduce the exposure to the active metabolite, mycophenolic acid MPA possibly due to a decrease in MMF solubility at an increased gastric pH. The clinical relevance of reduced MPA exposure on organ rejection has not been established in transplant patients receiving pantoprazole sodium for injection and MMF. You may take antacids while you are using pantoprazole delayed-release tablets if you are directed to do so by your doctor. Therefore, it is important to use the lowest doses and shortest duration of treatment necessary for the condition being treated. Stevens-Johnson-Syndrome, Lyell-Syndrome, Erythema multiforme and sensitivity to light. Animal studies have demonstrated that pantoprazole crosses the placental barrier; however, no teratogenic effects were observed. Doses of 15 mg per kg resulted in delayed fetal skeletal development. ATPase results in a duration of antisecretory effect that persists longer than 24 hours for all doses tested 20 mg to 120 mg. cyproheptadine pharmacist only



Pantozol forms and strengths

Pantoprazole delayed-release tablets may increase the risk of a serious form of diarrhea. Contact your doctor right away if stomach pain or cramps, severe or persistent diarrhea, or bloody or watery stools occur. Discuss any questions or concerns with your doctor. GPT mammalian cell-forward gene mutation assay, the in vitro thymidine kinase mutation test with mouse lymphoma L5178Y cells, and the in vivo rat bone marrow cell chromosomal aberration assay. This may not be a complete list of all interactions that may occur. Ask your health care provider if pantoprazole delayed-release tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. Safety and efficacy have not been established. AU TGA pregnancy category B3: Drugs which have been taken by only a limited number of pregnant women and women of childbearing age, without an increase in the frequency of malformation or other direct or indirect harmful effects on the human fetus having been observed. Studies in animals have shown evidence of an increased occurrence of fetal damage, the significance of which is considered uncertain in humans. This drug is only recommended for use during pregnancy when there are no alternatives and the benefit outweighs the risk. The reconstituted solution may be stored for up to 24 hours at room temperature prior to intravenous infusion and does not need to be protected from light. Pantoprazole sodium for injection should be administered intravenously over a period of at least 2 minutes. After first opening of the container, the product should be used within 3 months. What is pantoprazole, and how does it work mechanism of action? Do not stop taking these tablets without first talking to your doctor or pharmacist.



Children below 12 years

Tell your doctor or pharmacist. There are no known symptoms of overdose. National Jewish Health: “Timing Your Medication. Pantoprazole sodium USP is a white to off-white powder and is racemic. Pantoprazole has weakly basic and acidic properties. The following adverse reactions have been identified during postapproval use of pantoprazole sodium. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Diabetes Forecast: “Does It Matter When You Exercise? Pantoprazole may stop these and other medicines from working properly. Timing of elective surgery as a perioperative outcome variable: analysis of pancreaticoduodenectomy. Why has Pantozol Control been approved? Oral, 20 mg once a day in the morning. Dose can be increased to 40 mg once a day in the morning in the case of recurrence. The reconstituted solution may be stored for up to 24 hours at room temperature prior to intravenous infusion and does not need to be protected from light. The total volume from both vials should be administered intravenously over a period of at least 2 minutes. Hurlbut KM Eds: POISINDEXR System. MICROMEDEX, Inc. Pantoprazole delayed-release tablets are indicated for the short-term up to 8 weeks treatment of heartburn and other symptoms associated with GERD. Pantoprazole for injection is indicated for the short-term 7 to 10 days treatment of GERD in patients who are unable to continue taking pantoprazole delayed-release tablets. Pantoprazole for injection is not indicated for initial treatment of GERD. Pantoprazole delayed-release tablets may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use pantoprazole delayed-release tablets with caution. No differences in efficacy or safety between men and women are apparent. top 10 omifin



Indications and usage of pantozol

There was a 78% reduction in the C max and a 45% reduction in the AUC of MPA in patients receiving both pantoprazole and MMF. Safety and effectiveness of pantoprazole sodium for injection in pediatric patients have not been established. Use is not recommended and a decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother. In one study of gastric pH in healthy subjects, pantoprazole was administered orally 40 mg enteric coated tablets or intravenously 40 mg once daily for 5 days and pH was measured for 24 hours following the fifth dose. Several published observational studies suggest that proton pump inhibitor PPI therapy may be associated with an increased risk for osteoporosis-related fractures of the hip, wrist, or spine. The risk of fracture was increased in patients who received high-dose, defined as multiple daily doses, and long-term PPI therapy a year or longer. Patients should use the lowest dose and shortest duration of PPI therapy appropriate to the condition being treated. Pantoprazole is not removed by hemodialysis. In case of overdose, treatment should be symptomatic and supportive. This information should not be used to decide whether or not to take pantoprazole delayed-release tablets or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about pantoprazole delayed-release tablets. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to pantoprazole delayed-release tablets. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using pantoprazole delayed-release tablets. After administration of a single intravenous dose of 14C-labeled pantoprazole to healthy, extensive CYP2C19 metabolizers, approximately 71% of the dose was excreted in the urine with 18% excreted in the feces through biliary excretion. There was no renal excretion of unchanged pantoprazole. Take pantoprazole delayed-release tablets by mouth with or without food. Mycophenolate Mofetil MMF: Administration of pantoprazole 40 mg twice daily for 4 days and a single 1000 mg dose of MMF approximately one hour after the last dose of pantoprazole to 12 healthy subjects in a cross-over study resulted in a 57% reduction in the C max and 27% reduction in the AUC of MPA. This medicine has been prescribed for you only. Do not pass it on to others. Atazanavir used to treat HIV-infection. During 6 days of repeated administration of pantoprazole sodium for injection in patients with Zollinger-Ellison Syndrome, consistent changes of serum gastrin concentrations from baseline were not observed. See USP Controlled Room Temperature. amoxil



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Why has Pantozol Control been approved?


Pantozol dosing information

Appropriate studies on the relationship of age to the effects of pantoprazole have not been performed in the pediatric population. Safety and efficacy have not been established. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. Concomitant use of atazanavir or nelfinavir with proton pump inhibitors is not recommended. Co-administration of atazanavir or nelfinavir with proton pump inhibitors is expected to substantially decrease atazanavir or nelfinavir plasma concentrations and may result in a loss of therapeutic effect and development of drug resistance.

Common side effects of pantozol

Although serum half-life values increased to 7 to 9 hours and AUC values increased by 5- to 7-fold in hepatic-impaired patients, these increases were no greater than those observed in CYP2C19 poor metabolizers, where no dosage adjustment is warranted. These pharmacokinetic changes in hepatic-impaired patients result in minimal drug accumulation following once-daily, multiple-dose administration. No dosage adjustment is needed in patients with mild to severe hepatic impairment. Treatment with Pantoprazole Sodium for Injection should be discontinued as soon as the patient is able to receive treatment with Pantoprazole Sodium Delayed-Release Tablets or Oral Suspension.

Pantozol warnings

Take the tablets 1 hour before a meal without chewing or breaking them and swallow them whole with some water. Pantoprazole sodium for injection is indicated for the treatment of pathological hypersecretory conditions including Zollinger-Ellison Syndrome in adults. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource, but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately.

Spanish adolescents: Further evidence

Study 2 was a single-center, double-blind, parallel-group study to compare the clinical effects of pantoprazole sodium for injection and oral pantoprazole sodium. Division of Sleep Medicine at Harvard Medical School: “Sleep, Learning, and Memory. ECL-cell proliferation and gastric neuroendocrine NE-cell tumors. Gastric NE-cell tumors in rats may result from chronic elevation of serum gastrin concentrations. The high density of ECL cells in the rat stomach makes this species highly susceptible to the proliferative effects of elevated gastrin concentrations produced by proton pump inhibitors.

Due to extensive protein binding, pantoprazole is not readily dialyzable. There have been postmarketing reports of increased INR and prothrombin time in patients receiving proton pump inhibitors, including pantoprazole, and warfarin concomitantly. Increases in INR and prothrombin time may lead to abnormal bleeding and even death. Patients treated with proton pump inhibitors and warfarin concomitantly should be monitored for increases in INR and prothrombin time. Black, 11 Hispanic, 44 White, 1 other with a history of erosive esophagitis were randomized to receive either 20 or 40 mg of oral pantoprazole once per day for 10 days period 1 and then were switched in period 2 to either daily intravenous pantoprazole or placebo for 7 days, matching their respective dose level from period 1. Patients were administered all test medication with a light meal. diltiazem-ointment

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